Objective A large number of studies have demonstrated that Helicobacter Pylori(HP) is closely related to chronic atrophic gastritis(CAG), and the eradication of HP is often regarded as a key link in the clinical treatment of chronic atrophic gastritis. However, with the increase of drug resistance rate of HP eradication therapy in recent years, the bactericidal and bacteriostatic effects of traditional Chinese medicine have been highlighted. In recent years, there have been increasing reports on the combination of traditional Chinese medicine and western medicine to improve the eradication rate of HP. To this end, this paper systematically evaluated the efficacy and safety of Weifuchun combined with HP eradication in the treatment of HP-related chronic atrophic gastritis. Methods Randomized controlled trials of gastroenterol combined with HP eradication therapy for CAG from January 2001 to August 2020 were searched using computer systems from Wanfang Database, CNKI, Viper, Cochrane Library, PubMed and Embase databases. Data extraction and quality evaluation were carried out for the included literatures. A total of 9 included literatures were systematically evaluated by using the improved Jadad scale. The HP eradication rate, adverse reaction rate and overall efficacy rate in the included literature were Meta systematic evaluation using RevMan 5.3 software. Results ① A total of 9 randomized controlled trials were included, of which 3 were of high quality and the rest were of low quality. ② Meta results: the eradication rate of HP in the combined group[MD=3.41，95%CI(2.23，5.19)，Z=5.70，P＜0.000 01]. The incidence of adverse reactions was[MD=0.37，95%CI(0.18，0.79)，Z=2.57，P=0.01]. The overall efficacy rate [MD=3.88，95%CI(2.68，5.62)，Z=7.16，P＜0.000 01] was superior to the non-combined group. Conclusion HP eradication rate, adverse reaction rate and overall efficacy rate were significant in the group of gastroenterology combined with HP eradication. It indicates that for the treatment of CAG, the combination of HP eradication and gastroenterology on the basis of HP eradication treatment can further improve the eradication rate and overall efficacy rate of HP, and reduce the incidence of adverse reactions. However, due to the small number of included literatures and the low quality of the articles, more large sample and multi-center randomized controlled trials are needed to provide further effective data.