Shuanghuanglian injection is a Chinese formula prepared from three Traditional Chinese Medicines (TCMs) including Lonicera Japonica (Jinyinhua), Radix Scutellariae (Huangqin) and Fructus Forsythiae (Lianqiao), which can clear heat and detoxify, disperse wind and heat, act quickly, have good bioavailability, and have good results in the treatment of upper respiratory tract infection, pneumonia, tonsillitis and other diseases. In recent years, the adverse reactions caused by traditional Chinese medicine injection have increased significantly, and the adverse reactions caused by Shuanghuanglian injection are always in the first place. the adverse reactions involve the injury of many systems and organs of the human body, such as skin, digestive system, cardiovascular system and so on. In severe cases, anaphylactic shock may even occur. At present, the cause of sensitization of Shuanghuanglian injection is still controversial. This article will review the theory of traditional Chinese medicine, the material basis, the mechanism of anaphylactoid and other aspects, and discuss the causes of anaphylactoid, in order to provide suggestions for increasing the safety of Shuanghuanglian injection.