Objective To evaluate the function of extracts from Gastrodiae Rhizoma in reducing blood lipid. Methods Rats were randomly divided into normal group, model group, simvastatin group(4 mg/kg), Gastrodiae Rhizoma extracts high dose group (1 g/kg), low dose group (0.2 g/kg). The normal group was fed with normal diet, and the other groups were fed with high-fat diet, the treatment were lasted for 120 d. At the end of the treatment, lipid levels（TG, TC, HDL-C, LDL-C） and liver AST, ALT were measured, also liver histological changes were observed. Results Compared with the normal group, TC and LDL-C in the model group increased significantly(P<0.05). Compared with the model group, the high dose group of Gastrodiae Rhizoma extracts decreaseed the levels of TC and LDL-C(P<0.05) . It was also reduced the levels of serum (AST), liver tissue AST and ALT(P<0.05). The low dose group of Gastrodiae Rhizoma extracts only decreaseed the LDL-C level in serum and the levels of AST, ALT in liver tissue (P<0.05). Both Gastrodiae Rhizoma extracts groups were able to improve liver tissue damage. Conclusion It is suggested that the Rhizoma Gastrodiae extracts could reduce the level of blood lipid and improve liver injury, have the function in reducing blood lipid.