Objective To explore the difference of clinical efficacy between Zuojin Pill and conventional western medicine in the treatment of gastroesophageal reflux disease of liver and stomach heat stagnation type. Methods To search the datebase of CBM, VIP, CNKI, Wanfang database, PubMed, Cochrane Library and EMBASE. Meta analysis was performed by revman5.3 after the relevant data were extracted and literature bias was analyzed. Results 22 studies involving 1 543 patients were included. Meta analysis results showed that: Zuojin Pill was superior to conventional western medicine in terms of clinical efficiency, improvement of acid reflux symptoms, endoscopic efficiency results and recurrence rate results. Conclusion Compared with conventional western medicine, Zuojin Pill has significant advantages in clinical efficiency, improvement of acid reflux symptoms, recurrence rate and safety evaluation. However, due to the limitation of reports, high-quality large sample test is still needed to verify.