The treatment of primary liver cancer should be based on syndrome differentiation, focusing on the pathogenesis of qi stagnation and blood stasis, weakness of spleen. Doctors need to be familiar with the taste of drugs to serve the clinic. According to the theory of “seeking the same qi”(the same substance attracts each other), each organ has its own favorite taste. On one hand, hawthorn which is sour enters the liver to feed the liver, promoting qi and blood circulation and stopping bleeding without leaving blood stasis; On the other hand, hawthorn which is sweet enters the spleen, boosting digestion and immunity, promoting diuresis and phlegm, nourishes the spleen to make the liver better and guides drugs into the liver and spleen. Hawthorn, a drug effective, repairs defects and harmonizes the internal organs. Clinical use should avoid too sour taste, so as not to damage the spleen. Only by harmonizing the five flavors, can we achieve the goal of “the balance of Yin and Yang, and peace of mind”. Meanwhile, we pay attention to the combination of modern pharmacology to ensure the therapeutic effect and the clinical results are very significant.