Objective To analyze the pharmacological mechanism of Bupleurum chinense-Pueraria lobata regulating fever symptoms of Mycoplasma pneumoniae pneumonia based on network pharmacology and molecular docking technology. Methods TCMSP database was used to obtain the main chemical components and targets of Bupleurum chinense and Pueraria lobata, and the active components of traditional Chinese medicine were screened according to pharmacokinetics; Gencards and OMIM database were used to obtain the main targets of MPP fever symptoms, and STRING platform was used to analyze protein-protein interaction, construct PPI network and mine potential protein function modules in the network. The “drug component target” and its biological processes and pathways were analyzed by Metascape platform, and then the “Bupleurum chinense-Pueraria lobata-MPP fever target -signaling pathway” network was constructed by using Cytoscape 3.7.2 software. Finally, the molecular docking was verified by autodocktools1.5.6 and using Pymolwin to draw the docking diagram of main active components of traditional Chinese medicine and key target molecules. Results Quercetin, kaempferol, β-sitosterol and formononetin were the core active components of Radix Bupleuri Puerariae in regulating fever symptoms of Mycoplasma pneumoniae pneumonia. The core targets were IL-6, TNF and IL-1β. Molecular docking also showed that 88.24% of the patients had a docking score greater than 4.25 and 72.55% had a docking score greater than 5. Most of the targets had good binding activity with the components. Quercetin, kaempferol, formononetin and β - sitosterol have strong binding activity with the three targets. The biological pathway of Bupleurum chinense-Pueraria lobata regulating MPP fever symptoms mainly acts on IL-17 signaling pathway and NF-κB signaling pathway, and its function is mainly to regulate lung inflammation and immune disorder. Conclusion This study preliminarily revealed the multi-component, multi-target and multi-channel characteristics of Bupleurum chinense-Pueraria lobata in regulating MPP fever symptoms, and provided the basis for the clinical development and utilization of Bupleurum chinense-Pueraria lobata.