Objective Based on data mining articles on the treatment of hypothyroidism in the traditional chinese medicine（TCM） in the past 10 years, analyze its medication rules through the TCM inheritance support platform(V2.5 version)in order to guide clinical medication. Methods To search the literature on the treatment of hypothyroidism with traditional Chinese medicine which was published in the CNKI, Wanfang Medical Network and VIP in the past 10 years ,screening and constructing a database of relevant prescriptions, sorting out the drugs,and drawing the rules of medication. Results A total of 133 literatures and 140 Chinese medicine prescriptions were screened, involving 203 Chinese medicines. The analysis showed that the common drug pairs, common core drug pairs and new prescriptions of high-frequency Chinese medicine, four qi and five flavors, meridian distribution, and association rules were obtained. Conclusion Articles on the treatment of hypothyroidism with traditional chinese medicine included in CNKI, Wanfang Med Online and VIP in the past 10 years, paying attention to choosing the drug properties were warm and neutral ,the drug tastes were sweet and pungent, and the meridians were spleen, kidney and liver. The efficacy of drug is mainly to warm and tonify kidney-yang, invigorate qi and spleen, eliminate dampness and diuresis, nourish blood and yin, provides strong literature support for clinical treatment of hypothyroidism.