The novel coronavirus, COVID-19, is an acute respiratory infectious disease caused by new coronavirus. The six meridians of treatise on febrile diseases reflect that the pathogenic factors gradually go from the beginning of the sun to the end of Jueyin, which is similar to the process of COVID-19 from the beginning of exogenous to multiple organ dysfunction, so it is feasible to explain the evolution of the disease from the perspective of six meridians. COVID-19 started in the sun at the beginning. Exogenous pathogenic diseases can be introduced into Shaoyang and Yangming from the surface and the inside. When the disease is in Sanyang channel, it should be mainly exorcism. If the body is deficiency or is not treated or mistakenly treated, the pathogenic diseases can be quickly introduced into Sanyin channel, which can change into other syndromes. When the disease is in Sanyin channel, it should be mainly supporting and exorcism. COVID-19 can be treated as a whole by single channel, combined disease, multiple syndromes and concurrent syndromes. In addition, the six meridians syndrome differentiation should follow the principles of expelling evil Qi, protecting stomach qi, retaining body fluid and balancing the urgency. I hope that a little knowledge can play a role in the diagnosis and treatment of COVID-19.