Objective To systematically evaluate the clinical efficacy of bupleurum falcatum plus dragon bone and oyster shell decoction(CHJLGMLT) in the treatment of coronary heart disease with anxiety. Methods Comprehensive retrieval was performed for the clinical randomized controlled trials(RCTS) for CHJLGMLT in coronary heart disease with anxiety in databases like PubMed, EMbase, CNKI, VIP, WANFANG, etc., the search time is from database creation to May 2020. By screening and quality assessment(Cochrane evaluation), the data of the included literature were extracted and sorted out. Finally, the RevMan 5.3 software was employed for Meta-analysis. Results 8 relevant literatures were included in this study. The results of meta-analysis showed: CHJLGMLT combined with western medicine(coronary heart disease basic medicine and anti-anxiety drugs) was significantly better than western medicine group in imroving anxiety[HAMA score MD=-4.06，95% CI (-4.94，-3.18), P＜0.000 01; SAS score MD=-5.45, 95%CI(-6.47，-4.43), P＜0.000 01]; The clinical efficacy of angina pectoris was significantly better than that of western medicine group[OR=5.16, 95% CI(2.68, 9.94), P<0.000 01], Significant improvement of restricted physical activity(Seattle Angina scale)[MD = 11.54, 95% CI(8.15, 14.93), P<0.000 01], The traditional Chinese medicine symptom score was significantly lower [MD=-2.29, 95% CI (-2.57, -2.01), P<0.000 01]. Conclusion CHJLGMLT combined with western medicine can more effectively improve the anxiety state, angina symptoms, the degree of physical activity restriction,as well as the traditional Chinese medicine symptoms.