Objective To systematically evaluate the efficacy of Xuebijing combined with western medicine therapy in the treatment of acute pancreatitis. Methods Randomized controlled trials of Xuebijing combined with western medicine therapy versus western medicine therapy in the treatment of acute pancreatitis from CNKI, Wanfang, VIP, Pubmed, Cochrane Library,Web of Science and Embase databases were searched from the time of establishment to January 2021.Screening was conducted according to the inclusion and exclusion criteria, and Meta-analysis was conducted using Revman 5.3 software after data extraction. Results A total of 61 studies and 4 868 patients were included.The results of Meta-analysis showed that Xuebijing combined with western medicine therapy in the treatment of acute pancreatitis had a higher total effective rate[RR=1.20,95%CI(1.17,1.24)],shorter time to relieve abdominal pain[MD=-1.64,95% CI(-1.87,-1.40)]and abdominal distension[MD=-1.48,95%CI(-1.78,-1.18)], and shorter hospitalization time[MD=-4.84,95%CI(-6.78,-2.90)]than western medicine alone.The effect of decreasing blood amylase[MD=-112.45,95%CI(-152.24,-72.67)],white blood cells[MD=-2.44,95%CI(-3.13,-1.76)],CRP[SMD=-2.12,95%CI(-2.51,-1.72)],IL-6[ SMD=-2.11,95%CI(-2.54,-1.69)],IL-8[SMD= -1.98,95%CI(-2.57,-1.40)],TNF-α[SMD=-2.06,95%CI(-2.43,-1.68)] was stronger. Conclusion Xuebijing combined with western medicine therapy in the treatment of acute pancreatitis has a good effect and is worth popularizing. However, due to the small sample size, low literature quality, high heterogeneity and publication bias, the conclusions still need to be further verified.