Objective To explore the characteristics of medicines used for Bi disease in A Guide to Clinical Practice with Medical Record. Methods Data mining technology was used to count the frequency of medicine use, return to sex, conduct association rules analysis,and so on. Results A total of 83 prescriptions were screened, involving a total of 125 flavors of traditional Chinese medicine. The top 5 most frequently used were Guizhi, Poria, Atractylodes, Angelica, and bitter almonds. In terms of medicinal property， Ye Tianshi treated Bi diseases with warm and followed by sweet. The Jing mainly involves the lung, spleen, liver, heart, kidney and stomach. Association rules result in 10 pairs of common combinations,high-frequency traditional Chinese medicine is divided into 4 categories, and a core combination is obtained by complex network analysis. Conclusion Ye Tianshi often treated Bi disease from the perspective of collateral disease, either by dredging, supplementing, or both。And attaches importance to the lungs and spleen, pays attention to reconciling Qi and blood camps, and is good at the treatment of Qijing.