Objective To explore the mechanism of Hedysarum Multijugum Maxim.and Chuanxiong Rhizoma for ischemic stroke based on network pharmacology. Methods The active chemical components and targets of Hedysarum Multijugum Maxim. zand Chuanxiong Rhizoma were obtained from TCMSP database. Targets were converted to genes by Uniprot database. Components-targets network were established by Cytoscape 3.8.0. The targets of ischemic stroke were obtained from OMIM、 DisGeNET、 TTD database and literatures, which constituted disease-targets network. Components-targets network and disease-targets network were merged and the potential core targets were predicted. Potential core targets were entered into the STRING platform to obtain a protein-protein interaction(PPI) network. Finally, GO functional enrichment analysis and the KEGG enrichment analysis of potential core targets were calculated. Results There are 18 predicted core targets for 17 compounds and the core targets includined IL1B、 NOS3、 CASP3、 BDNF, which may via regulating PI3K/AKT signaling pathway, MAPK signaling pathway, TLR signaling pathway, NF-κB signaling pathway, etc, affected regulations of NO biosynthesis, apoptosis, inflammation and immune response, angiogenesis and organ regeneration, etc, so as to participate in a series of physiological and pathological processes of ischemic stroke. Conclusion Network pharmacology exhibited multi-component, multi-target, and multi-mechanism biological effects of Hedysarum Multijugum Maxim and Chuanxiong Rhizoma, which provides a scientific basis for further study.