Objective To investigate the effect of Compatibilities of Ramulus Cinnamomi(RC) Regulating Ying and Wei on tumor necrosis factor-α,interleukin-1β，interleukin-6 and the ankle Bone Destruction in rheumatoid arthritis model rats. Methods Eighty male Wistar rats were randomly divided into normal group 10 rats, remaining the other rats' were induced by type II collagen to establish CIA model, successfully modeled rats were randomly divided into the CIA the model group, the RC Radix Paeoniae Albagroup, the RC Radix Paeoniae Rubra group, the RC Chinses angelica group, the RC Prepared rehmannia glutinosa group, the methotrexate group, 10 rats in each group. All rats were intragastrically administered, once per day for 21 successive days. The changes of arthritis index and paw volume were observed. The serum levels of TNF-α， IL-1β and IL-6 were determined. Pathological changes of ankle joint were detected by HE staining. Results Compared with the CIA model group, AI was significantly alleviated in RC Radix Paeoniae Alba, RC Radix Paeoniae Rubra, RC Chinses angelica and the methotrexate group（P<0.05）. The swelling degree of the joints and Serum levels of TNF-α, IL-6 were decreased significantly in all administered groups（P<0.05 or P<0.01）. Pathological changes of ankle joint were also improved as well. Conclusion The compatibilities of Ramulus Cinnamomi for Regulating Ying and Wei had certain inhibition on joint arthritis and Bone Destructionof CIA rats, which might be effective compatibilities for treating rheumatoid arthritis．