Objective To observe the effect and the mechanism of Jiangni Tongfu recipe for the treatment of non-erosive reflux disease （NERD） with the sydromen of dampness-heat of spleen and stomach. Methods Sixty NERD patients with syndrome of dampness-heat of spleen and stomach were randomly assigned into the treatment group and the control group. The treatment group was treated with Jiangni Tongfu recipe granules combined with esomeprazole for 8 weeks. The control group was treated with esomeprazole 40mg per day for 8 weeks. The scores symptom of RDQ scale and TCM symptoms were observed before-and-after treatment,the esophageal pressure and the esophagus 24 hours pH value before-and-after treatment was measured and evaluated, respectively. Results The scores of the RDQ scale of the two groups significantly improved, and the improvement of the treatment group was better than that of the control group. The total clinical effective rate in the treatment group was 96.67%, while it was 86.67% in the control group .The treatment group was more effective than the control group. Both groups improved the LESP of NERD patients, and the treatment group was superior than the control group. Statistical analysis of the DeMeester score of the esophagus 24 hours pH value revealed that the two groups were reduced and statistically significant for before-and-after treatment（P<0.05）. Conclusion Jiangni Tongfu recipe combined with esomeprazole can improve clinical symptoms of NERD patients. According to the esophageal kinetic monitoring indicators, it is concluded that the treatment group can increase the pressure of lower esophageal sphincter (LESP), improve the esophageal motility disorder, and strengthen the esophageal body movement function, thus play the role of anti esophageal reflux and acid suppression.