Objective To explore the symptoms spectrum of acupuncture and moxibustion at Zhongzhigou point in ancient books, and summarize the clinical application regularity of Zhigou point, so as to provide reference for clinical acupoint selection of acupuncture and moxibustion. Methods Using bibliometric research methods, the symptoms spectrum of acupuncture and moxibustion at Zhigou single acupoint and its compatibility were selected, and a database was established. SPSS22.0 statistical software was used to analyze the symptoms. Results There are 8 kinds of disease in Zhigou acupoint and 29 kinds of disease in combination, especially in spleen disease and liver and gallbladder disease. Hypochondriac pain, constipation and arthralgia syndrome are the dominant diseases in Zhigou acupoint. The main acupoints of Zhigou acupoint are Zusanli, Zhangmen, Daling, Hegu, Jianzhi and Quchi. Conclusion Zhigou acupoint is widely used in clinic and has the characteristic of "regulating qi", which can be used for the treatment of Qi disorders.