Objective To explore the biological mechanism of Yiqi Liangxue Shengji Decoction protecting against recurrence of angina after angiographically percutaneous coronary intervention by network pharmacology. Methods The effective components and corresponding targets of Yiqi Liangxue Shengji Decoction were screened by TCMSP database and Component-target network was constructed by Cytoscape software. Then searching angina related targets from OMIM and GeneCards database. protein-protein interaction network was analyzed using STRING database, and the core target is obtained through the CytoNCA plug-in. Results After selection, 252 potential target genes of Yiqi Liangxue Shengji Decoction and 1740 for AP were obtained. The active ingredients, such as kaempferol, quercetin, and luteolin mainly act on RELA, MAPK14, MAPK1 and other key targets. Through fluid shear stress atherosclerosis, TNF, IL-17 signaling pathway and other signaling pathways, playing anti-inflammatory and other functions in the treatment of angina pectoris. Conclusion The potential mechanism of Yiqi Liangxue Shengji Decoction for recurrence of angina after angiographically percutaneous coronary intervention has been explored based on the multi-component, which provides a basis for the follow-up scientific research and clinical application of Yiqi Liangxue Shengji Decoction in the treatment of angina and extended indications.