Objective To observe the effect of Zhichou Decoction on the tic behavior and the expression of TNF-α, IL-6 and IL-1β in serum and striatum of rats in tic disorder(tic disorder,TD), and to explore its mechanism. Methods The model was made by intraperitoneal injection of iminodipropionitrile(IDPN), and after the model group was established, the rats were randomly divided into model group, Zhizhou Decoction group and thiapride hydrochloride group, and a blank control group was established. Each group was given 14 days of corresponding drug-gavage intervention. After 7 and 14 days of drug intervention, rat behavior score was performed. After the last behavior score, rat serum TNF-α, IL-6 and IL-1β level was detected by ELISA method and the expression levels of TNF-α, IL-6 and IL-1β mRNA and protein in rat striatum were measured by fluorescence quantitative PCR and immunoblotting, respectively. Results ①After 7 days of drug gavage, compared with the control group, the scores of rigid behavior were significantly decreasedin the zhichou decoction group and thiapride hydrochloride group(P<0.01), and the motor behavior score was not statistically significant(P>0.05). After 14 days of drug gavage, compared with the control group, the scores of rigid behavior and motor behavior were significantly decreasedin the zhichou decoction group and thiapride hydrochloride group(P<0.01).②Serum and striatum TNF-α, IL-6 and IL-1β expression levels were compared: Zhichou Decoction group and thiapride hydrochloride group were significantly lower than control group (P<0.01). Conclusion Zhichou Decoction can obviously improve the motor behavior and stereotype behavior of the model rats, and its mechanism may be related to the decrease of serum、striatum TNF-α, IL-6 and IL-1β expression level.