Abstract:Objective To discuss the correlation between chronic kidney disease(CKD) and TCM constitution by analyzing the distribution of CKD TCM constitutional types. Methods Relevant information was extracted with computer retrieval from the Chinese National Knowledge Infrastructure(CNKI), WANFANG DATA, China Science and Technology Journal Database(VIP), China Biomedical Database(CBM), Medline, Embase, and The Cochrane Library. Controlled study was conducted by collecting cases with CKD TCM connotational types. Revman 5.3 and Stata16 software were used as tools to analyze the heterogeneity, offset risk tests and Meta-analysis of single group rate, and effect values were expressed with 95% confidence intervals for all outcomes. Results A total of 11 case-control studies were included, with a total of 1 685 CKD patients and 1 300 healthy people. Among them, there were 29.82% patients with Qi deficiency constitution, ranked first; 22.13% with blood stasis, ranked second; 21.53% with Yin deficiency, ranked third; and 10.95% with dampness-heat, ranked last. The distribution and share of the other six constitution types in the CKD population were all less than 10%. Conclusion The occurrence and progression of CKD is closely related to constitution of Qi deficiency, blood stasis and Yin deficiency. The above conclusions may be subject to the risk of bias due to factors such as the quantity and quality of the included primary literature, and thus requires further study.