Objective Through network pharmacology, the“the warming and ascending three Yin, descending metal and storing Yang law”(温升三阴，肃金秘阳法), was analyzed to explore the potential anti-tumor target and mechanism in the treatment of hepatocellular carcinoma, so as to provide targeted guidance for the follow-up research. Methods The TCMSP database was used to screen the chemical components contained in the corresponding traditional Chinese medicine under the method of“the warming and ascending three Yin, descending metal and storing Yang law” and to predict their action targets. The relevant targets of hepatocellular carcinoma were obtained through Gene Cards database and OMIM database. Cytoscape 3.7.2 software was used to construct drug-disease-target relationship network. R language was used to obtain the intersection target protein of the two. Protein-protein interaction network analysis was carried out on the STRING platform, and Molecular docking verification of key targets and related active chemical components was performed. Gene Ontology(GO) functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment analysis were performed using DIVID database. Results The key components in the treatment of primary liver cancer were quercetin, β-sitosterol, kaempferol and stigmasterol. The key target genes mainly included PTGS2, STAT3, HSP90Aa1 and AKT1. In this method, the main biological processes may be signal transduction, redox process, drug reaction, apoptosis, inflammation and so on. The mechanism of action may be related to PI3K/Akt signaling pathway, TNF signaling pathway, hepatitis B signaling pathway and MAPK signaling pathway. Conclusion The therapeutic effect of“the warming and ascending three Yin, descending metal and storing Yang law” on hepatocellular carcinoma may be multi-target, multi-pathway and multi-level. It can be speculated that quercetin and kaempferol may be the two more important active components. PTGS2, STAT3, and AKT may be the main targets, and PI3K/Akt signaling pathway, TNF signaling pathway may be the two more important signaling pathways that this method plays a role in.