This paper studies the appropriateness of higher education discipline and modern economic system in Yunnan Province. The partial least squares model is used to analyze the effects of discipline supply and industrial economic growth in Yunnan from 2013 to 2020. The main findings are as follows, (1) All the factors of yunnan higher education discipline supply contribute to the industrial economic growth in Yunnan province, and the discipline distribution and funding supply have more significant effects on the industrial economy. (2) The degree of contribution of agricultural graduates to primary industry is the highest, and the degree of balance between agricultural and primary industry is better. The supply scale of science and engineering oriented to the secondary industry has a small growth rate, and the contribution of engineering graduates to the secondary industry is higher, while the contribution of science graduates to the secondary industry is slightly lower than that of some disciplines. Modern service disciplines oriented to the tertiary industry have a relatively good supply-demand balance and contribute to the overall industrial economic growth. (3) The contribution of graduates from different disciplines to industrial economic growth is different, and the contribution of medical graduates is the most significant. Based on the analysis of the results and the reality of Yunnan, some policy suggestions are put forward.