Objective To investigate the clinical characteristics of co-morbidity and complications diseases of hospitalized patients with gout, and analyze the factors that can contribute to them. Methods The demographic information, medical history, laboratory examination and other data of 2087 gout patients hospitalized in the Yunnan Provincial Hospital of Traditional Chinese Medicine from January 2016 to June 2021 were analyzed statistically in order to get the distribution of co-morbidity and complications diseases, along with analyzing the affecting factors. Results According to the investigation, it was found that the total prevalence of co-morbidity and complications diseases in patients with gout was 88.88%. The metabolic diseases shared the most portion in co-morbidity, including hyperlipidemia in 360 cases (17.25%), diabetes mellitus in 310 cases (14.85%), fatty liver in 731 cases(35.03%); cardiovascular diseases: hypertension in 1015 cases(58.63%), coronary atherosclerotic heart disease in 220 cases(9.85%), coronary artery calcification in 86 cases(4.12%); lung damages: pulmonary nodules in 191 cases(9.15%), pulmonary fibrosis in 35 cases(4.12%); other co-morbidity: osteoarthritis in 667 cases (31.96%) and liver injury in 109 cases (5.22%). The renal diseases were the most common complications diseases, including renal calculi in 389 cases (18.64%), gouty nephropathy in 244 cases(11.69%), and renal failure in 179 cases(8.58%). There are many risk factors affecting the occurrence of co-morbidity and complications diseases, including age, occupation, long course of disease, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), low-density lipoprotein, high-density lipoprotein, triglyceride, uric acid(UA), creatinine(Cre), etc. Conclusion The incidence of co-morbidity and complications diseases in gout patients is as high as 88.88%. The most common co-morbidity are metabolic diseases, among which the incidence of fatty liver is the highest; the most common complications diseases are renal diseases, among which the incidence of renal calculi is the highest. Age, occupation, long course of disease, ESR, and CRP are important risk factors.