Objective To systematically evaluate the efficacy of safflower yellow injection combined with conventional treatment to compare with the conventional therapy in the treatment of Coronary Heart Disease Angina Pectoris, so as to provide evidence-based reference for clinical medication application. Methods Randomized controlled trials(RCTs) about safflower yellow injection preparation treating Angina Pectoris of Coronary Heart Disease from PubMed, Medline, Embase, The Cochrane Library, CNKI, Wanfang Database, CQVIP, and Duxiu Datebase were retrieved and these references were collected from January 1, 2009 to December 31, 2020. Meta analyses were performed with RevMan 5.4 Software. A total of 19RCTs(2050 cases were covered, including 1027 cases in experimental group and 1023 in control group). Results The total clinical effective rate assessment analysis was conducted in 10 studies and the findings showed the total clinical effective rate of the experimental group was better than the control group [OR=3.32, 95%CI（2.18, 5.06), Z=5.57, P<0.000 01]. The evaluation analysis of the ECG consisted of nine studies and the results showed that the experimental group was superior to the control group [OR=1.33, 95%CI(1.15, 1.54), Z=3.89, P<0.000 01]. The assessment analysis of angina improvement included seven studies, and the results showed that the experimental group was superior to the control group [OR=4.98, 95%CI(3.45, 7.19), Z=8.59, P<0.000 01]. The evaluation analysis of whole blood high shear viscosity included four studies, and the results showed that the experimental group was superior to the control group [MD=-0.35, 95%CI(-0.52, -0.19), Z=4.24, P<0.000 1]. The evaluation analysis of whole blood low shear viscosity included four studies, and the results showed the experimental group surpassed the control group[MD=-1.18, 95%CI(-2.22, -0.14), Z=2.22, P<0.000 01]. The evaluation analysis of improvement in plasma viscosity consisted of studies, and the results showed that the experimental group was better than the control group[MD=-0.14, 95%CI(-0.18, -0.09), Z=5.54, P<0.000 01]. The assessed analysis of the improvement in hematocrit included two studies, and the results showed that the experimental group was superior to the control group[MD=-2.15, 95%CI(-5.70, 1.40), Z=1.19]. The evaluation analysis of fibrinogen improvement included two studies, the results that the experimental group surpassed the control group[MD=-0.27, 95%CI(-0.92, 0.37), Z=0.83, P<0.000 01]. The assessment analysis of serum BNP improvement included 2 studies, and the results showed that the experimental group was superior to the control group [MD=-38.86, 95%CI(-61.37, -16.35), Z=3.38]. The evaluation analysis of serum CRP improvement included 2 studies, the findings showed that the experimental group was superior to the control group[MD=-2.37, 95%CI(-5.56, 0.81), Z=1.46]. Conclusion The routine treatment of safflower yellow injection combined with western medicine has obvious total clinical effect rate in improving patients' ECG, blood rheology, reducing serum BNP, CRP and other indicators, which is better than the conventional treatment of western medicine.