Abstract:Objective To evaluate the clinical efficacy and safety of acupuncture for oculomotor paralysis based on Meta-analysis. Methods By searching CNKI, WanFang Data, VIP, Chinese Biomedical Literature Database, PubMed, Embase database from January 2011 to October 2021, relevant clinically controlled trials of oculomotor paralysis by acupuncture were collected. Meta-analysis was performed using RevMan 5.3 software. Results A total of 37 articles (2475 cases) were included, the results showed that compared with the control group, acupuncture treatment of oculomotor paralysis improved the size of palpebral fissure [MD=1.29, 95%CI(0.95, 1.62), Z=7.45, P<0.000 01] and pupil [MD=-0.42, 95%CI(-0.57, -0.27), Z=5.42, P<0.000 01], diplopia score[MD=-1.10, 95%CI(-1.27, -0.93), Z=12.76, P<0.000 01], exotropia deviation [MD=-6.70, 95%CI(-8.65, -4.75), Z=6.73, P<0.000 01)], the range of eye movement [MD=0.79, 95%CI (0.47, 1.10), Z=4.92, P<0.000 01)] and total efficiency[RR=1.32, 95%CI(1.26, 1.37), Z=13.38, P<0.000 01]. Conclusion Based on available data, it was proved that acupuncture combined therapy was better than other therapies in treating oculomotor paralysis, especially in improving the size of palpebral fissure and pupil, diplopia score, exotropia deviation, the range of eye movement and overall effectiveness.