针刺治疗动眼神经麻痹的Meta分析*
作者:
作者单位:

(1. 北京中医药大学,北京 100029;2. 北京中医药大学东方医院,北京 100078)

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中图分类号:

R246.82

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收稿日期: 2021 - 10- 11
* 基金项目: 国家重点研发计划资助(2018YFC1704101)
第一作者简介: 王子杨(1996-),女,在读硕士研究生,研究方向:中西医结合防治视神经病变。
△通信作者: 孙艳红,E-mail:syh735@126.com


Meta-analysis of Clinical Efficacy and Safety of Acupuncture for Oculomotor Paralysis
Author:
Affiliation:

(1. Beijing University of Chinese Medicine, Beijing 100029, China;2. Dongfang Hospital Beijing University of Chinese Medicine, Beijing 100078, China)

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    摘要:

    目的 系统评价针刺治疗动眼神经麻痹的临床疗效及安全性。方法 检索2011年1月至2021年10月中国期刊全文数据库(CNKI)、万方数据知识服务平台(WanFang Data)、中国生物医学文献数据库(CBM)、维普中文科技期刊数据库(VIP)、PubMed、Embase等中英文数据库,收集有关针刺治疗动眼神经麻痹的临床对照试验。使用RevMan5.3软件进行Meta分析。结果 共纳入37篇文献,2475个病例,合并Meta分析结果显示,针刺治疗动眼神经麻痹能改善患者的眼裂[MD=1.29,95%CI(0.95,1.62),Z=7.45,P<0.000 01];瞳孔大小[MD=-0.42,95%CI(-0.57,-0.27),Z=5.42,P<0.000 01];复视评分[MD=-1.10,95%CI(-1.27,-0.93),Z=12.76,P<0.000 01];斜视度[MD=-6.70,95%CI(-8.65,-4.75),Z=6.73,P<0.000 01) ];眼球活动度[MD=0.79,95%CI(0.47,1.10),Z=4.92,P<0.000 01];总有效率[RR=1.32,95%CI(1.26,1.37),Z=13.38,P<0.000 01)];且均优于对照组。结论 基于现有数据可证明,针刺疗法或针刺联合疗法治疗动眼神经麻痹临床效果显著。

    Abstract:

    Objective To evaluate the clinical efficacy and safety of acupuncture for oculomotor paralysis based on Meta-analysis. Methods By searching CNKI, WanFang Data, VIP, Chinese Biomedical Literature Database, PubMed, Embase database from January 2011 to October 2021, relevant clinically controlled trials of oculomotor paralysis by acupuncture were collected. Meta-analysis was performed using RevMan 5.3 software. Results A total of 37 articles (2475 cases) were included, the results showed that compared with the control group, acupuncture treatment of oculomotor paralysis improved the size of palpebral fissure [MD=1.29, 95%CI(0.95, 1.62), Z=7.45, P<0.000 01] and pupil [MD=-0.42, 95%CI(-0.57, -0.27), Z=5.42, P<0.000 01], diplopia score[MD=-1.10, 95%CI(-1.27, -0.93), Z=12.76, P<0.000 01], exotropia deviation [MD=-6.70, 95%CI(-8.65, -4.75), Z=6.73, P<0.000 01)], the range of eye movement [MD=0.79, 95%CI (0.47, 1.10), Z=4.92, P<0.000 01)] and total efficiency[RR=1.32, 95%CI(1.26, 1.37), Z=13.38, P<0.000 01]. Conclusion Based on available data, it was proved that acupuncture combined therapy was better than other therapies in treating oculomotor paralysis, especially in improving the size of palpebral fissure and pupil, diplopia score, exotropia deviation, the range of eye movement and overall effectiveness.

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