Traditional Chinese medicine pharmacy is the core main course of Chinese pharmacy, Chinese medicine resources and development, Chinese herbal medicine cultivation and identification in our university. It took more than fifty years to complete the teaching tasks of more than 10 000 students, but there are also problems such as poor teaching effect in some classrooms, limited teaching resources, and lack of a comprehensive and effective evaluation system. After the summary and innovative design of the teaching and research department and the teaching team, we still implement the principles of “grasping the main line and breaking the difficult points” in classroom lectures,“making supplements and eye-opening” online resources, and“casting foundations and re-applications” in practical training. It puts forward the design idea of “one center, two levels, three innovative teaching methods” to reconstruct the curriculum to realize the integration of explicit and implicit curriculum ideology and politics, online and offline mixed teaching, maximizing the output of limited resources, and international training. Innovate achievements and cultivate "four-ability" compound application-oriented talents.