Objective The menopause insomnia women mostly suffer from heart, liver, kidney at the same time, who are fit for three organs treated simultaneously. Methods 210 menopausal women with insomnia were enrolled in different groups to get the effect of treatment and the improvement of symptoms associated with menopause. P<0.05 was considered statistically significant. Results Clinical comparison showed that the total effective rate of sleep improvement was statistically different from that of the control group(P<0.01). Through the heart, liver and kidney coadjustment prescription, the menopausal symptoms of insomnia women also significantly improved, especially in hot flashes, sweating( χ2=28.613，P=0.000), fatigue( χ2=16.470，P=0.000) irritability( χ2=9.802，P=0.007) and other aspects of statistical differences. Conclusion The insomnia of menopausal women is the result of internal and external factors' interaction and the imbalance of multiple viscera. Therefore, A good curative effect will be achieved if clearing the main disease and syndrome and carefully distinguishing the heart, liver and kidney disorders in the clinical symptoms, taking account of the three viscera and the addition and subtraction in the dispatch of drugs were all treated.