基于CiteSpace的中医药防治脂肪肝病相关文献的可视化分析*
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作者单位:

(1. 云南中医药大学,云南 昆明 650500;2. 云南省南药可持续利用研究重点实验室 云南 昆明 650500;3. 上海中医药大学,上海 201203;4. 安徽中医药大学,安徽 合肥 230038)

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R259

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收稿日期: 2021 - 10- 18
* 基金项目: 国家自然科学基金地区科学基金项目资助(81760818);国家自然科学基金地区科学基金项目资助(82160898);云南省科技厅科技计划项目--中医联合重点项目资助[20182018FF001(-006)];云南省科技人才和平台计划(202105AG070012);云南省南药可持续利用研究重点实验室2021年开放课题(202105AG070012XS2242);云南省科技厅科技人才与平台计划-云南省中医药学分子生物学重点实验室(2019DG


CiteSpace-based Visual Analysis of Literature Related to Prevention and Treatment of Fatty Liver Disease by Traditional Chinese Medicine
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(1. Yunnan University of Chinese Medicine, Kunming 650500, China; 2. Yunnan Key Laboratory of Sustainable Utilization of Southern Medicine, Kunming 650500, China;3. Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;4. Anhui University of Traditional Chinese Medicine, Hefei 230038, China )

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    摘要:

    目的 借助CiteSpace软件对我国近20年中医药防治脂肪肝病的研究进行可视化分析。方法 检索2000年1月1日至2021年7月20日收录于中国知网、维普、万方的有关于中医药防治脂肪肝病相关文献,对年发文量、期刊来源、作者、关键词、研究机构进行可视化分析。结果 (1)总计检索文献1 427篇,最终纳入文献1 408篇。(2)发文量处于小幅度的波动,说明目前处于稳定发展。(3)期刊来源前3的期刊为广州中医药大学学报、光明中医和北京中医药大学学报。(4)发文量大于10篇的有10位作者,通过可视化分析(N=526,E=432),说明有432个合作关系路径,进一步说明作者之间合作密切;结合单位可视化分析可知(N=491,E=0),作者之间的合作多在同一个单位,缺乏跨地域合作。(5)文献共现关键词的结果展现了中医药防治脂肪肝病的研究方向,包括临床、实验以及研究进展3方面,而有效关键词聚类进一步展示中医药防治脂肪肝病研究的热点有临床观察、脂联素、决明子、临床研究、TNF-α、辨证论治、临床疗效。(6)关键词突显显示,非酒精性脂肪肝病与中医证型、数据挖掘、2型糖尿病、代谢组学以及肠道菌群的相关性是目前的热点。(7)高被引文献显示,2017年临床肝胆病杂志《非酒精性脂肪性肝病中医诊疗专家共识意见(2017)》、2005中西医结合肝病杂志《脂肪肝中医证型分类的文献分析》以及世界中医药《中医药治疗非酒精性脂肪性肝病的优势与展望》为中医药防治脂肪肝病的研究奠定了基础。结论 中医药防治脂肪肝病的文献主要涉及临床观察、实验研究和综述,近些年研究热点主要在辨证论治、数据挖掘用药规律、中医证型与代谢组学以及肠道菌群关联性,既总结了中医的临床经验,又通过相关指标客观化,为中医药防治脂肪肝病提供了研究基础和防治思路。

    Abstract:

    Objective To use CiteSpace software to visually analyze the research on the prevention and treatment of fatty liver with traditional Chinese medicine in my country in the past 20 years. Methods A search was made for the relevant literature on the prevention and treatment of fatty liver with traditional Chinese medicine collected on CNKI from January 1, 2000 to July 20, 2021, and the annual publication volume, journal sources, authors, keywords, and research institutions were visually analyzed. Results (1) 1 427 articles were retrieved, and 1 408 articles were finally included. (2) The volume of published documents fluctuates slightly, indicating that it is currently in stable development. (3) The top 3 journals of journal sources are Journal of Guangzhou University of Traditional Chinese Medicine, Journal of Guangming Traditional Chinese Medicine and Journal of Beijing University of Traditional Chinese Medicine. (4) There are 10 authors who have published more than 10 articles. Through visual analysis(N=526, E=432), it shows that there are 432 cooperative relationship paths, which further shows that the authors cooperate closely; combined with the visual analysis of the unit, it can be known(N=491, E=0), the cooperation between authors is mostly in the same unit, and there is a lack of cross-regional cooperation. (5) The results of co-occurring keywords in the literature show the research direction of TCM in the prevention and treatment of fatty liver disease, including clinical, experimental and research progress, and the effective keyword clustering further shows that the research hotspots of TCM prevention and treatment of fatty liver disease are clinical observations , Adiponectin, Cassia Seed, Clinical Research, TNF-α, Syndrome Differentiation and Treatment, Clinical Efficacy. (6) Key words highlight that the correlation between non-alcoholic fatty liver disease and TCM syndromes, data mining, type 2 diabetes, metabolomics, and intestinal flora is the current hot spot. (7) Highly cited literature shows that the 2017 Journal of Clinical Hepatobiliary Diseases "Non-alcoholic Fatty Liver Disease TCM Diagnosis and Treatment Expert Consensus(2017)", 2005 Journal of Integrated Traditional Chinese and Western Medicine "Fatty Liver TCM Syndrome Classification Literature Analysis" and World Traditional Chinese Medicine "Advantages and Prospects of Traditional Chinese Medicine in Treating Non-alcoholic Fatty Liver Disease" has laid the foundation for the research on the prevention and treatment of fatty liver disease by Traditional Chinese Medicine. Conclusion The literature on the prevention and treatment of fatty liver disease by traditional Chinese medicine mainly involves clinical observation, experimental research and review. In recent years, the research hotspots are mainly on syndrome differentiation and treatment, data mining and drug use rules, TCM syndrome types and metabolomics, and the association of intestinal flora. The clinical experience of traditional Chinese medicine, through the objectification of relevant indicators, provides the research foundation and prevention and treatment ideas for the prevention and treatment of fatty liver disease by traditional Chinese medicine.

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