Objective To use CiteSpace software to visually analyze the research on the prevention and treatment of fatty liver with traditional Chinese medicine in my country in the past 20 years. Methods A search was made for the relevant literature on the prevention and treatment of fatty liver with traditional Chinese medicine collected on CNKI from January 1, 2000 to July 20, 2021, and the annual publication volume, journal sources, authors, keywords, and research institutions were visually analyzed. Results (1) 1 427 articles were retrieved, and 1 408 articles were finally included. (2) The volume of published documents fluctuates slightly, indicating that it is currently in stable development. (3) The top 3 journals of journal sources are Journal of Guangzhou University of Traditional Chinese Medicine, Journal of Guangming Traditional Chinese Medicine and Journal of Beijing University of Traditional Chinese Medicine. (4) There are 10 authors who have published more than 10 articles. Through visual analysis(N=526, E=432), it shows that there are 432 cooperative relationship paths, which further shows that the authors cooperate closely; combined with the visual analysis of the unit, it can be known(N=491, E=0), the cooperation between authors is mostly in the same unit, and there is a lack of cross-regional cooperation. (5) The results of co-occurring keywords in the literature show the research direction of TCM in the prevention and treatment of fatty liver disease, including clinical, experimental and research progress, and the effective keyword clustering further shows that the research hotspots of TCM prevention and treatment of fatty liver disease are clinical observations , Adiponectin, Cassia Seed, Clinical Research, TNF-α, Syndrome Differentiation and Treatment, Clinical Efficacy. (6) Key words highlight that the correlation between non-alcoholic fatty liver disease and TCM syndromes, data mining, type 2 diabetes, metabolomics, and intestinal flora is the current hot spot. (7) Highly cited literature shows that the 2017 Journal of Clinical Hepatobiliary Diseases "Non-alcoholic Fatty Liver Disease TCM Diagnosis and Treatment Expert Consensus(2017)", 2005 Journal of Integrated Traditional Chinese and Western Medicine "Fatty Liver TCM Syndrome Classification Literature Analysis" and World Traditional Chinese Medicine "Advantages and Prospects of Traditional Chinese Medicine in Treating Non-alcoholic Fatty Liver Disease" has laid the foundation for the research on the prevention and treatment of fatty liver disease by Traditional Chinese Medicine. Conclusion The literature on the prevention and treatment of fatty liver disease by traditional Chinese medicine mainly involves clinical observation, experimental research and review. In recent years, the research hotspots are mainly on syndrome differentiation and treatment, data mining and drug use rules, TCM syndrome types and metabolomics, and the association of intestinal flora. The clinical experience of traditional Chinese medicine, through the objectification of relevant indicators, provides the research foundation and prevention and treatment ideas for the prevention and treatment of fatty liver disease by traditional Chinese medicine.