Objective To improve the management level of nosocomial infection, and to prevent and curb the occurrence of nosocomial infection. Methods According to the work specifications on the prevention, control and supervision and management of hospital infection formulated by the national health department, improve the hospital infection monitoring system, do a good job in the monitoring of hospital infections, strengthen the construction and supervision of key departments, do a good job in the dissemination and education of hospital infection knowledge, strengthen the quality management of hospital infection control, and continuously improve the work. Results After supervision and fine management according to law, the infection rate of our hospital has reached the requirements of the Ministry of Health. Conclusion It has given full play to the training, teaching, testing, guidance and supervision functions of the Infection Management Office of our hospital, based on scientific monitoring and taking infection management as the main means, and taking effective measures to ensure medical safety.