Objective To investigate the effect of Tongbixiaoti granules on the function of CRSsNP nasal mucosa. Methods Patients with chronic rhinosinusitis without nasal polyps were collected, and the patients were randomly divided into treatment group(Tongbixiaoti granules group) and control group(clarithromycin tablet group) by single blind method. They were respectively treated with Tongbixiaoti granules and clarithromycin tablets for 4 weeks. The VAS score of symptoms, Saccharin test and Lund Kennedy score of nasal endoscopy were observed before and 2 weeks and 4 weeks after treatment. T-test was used for statistical analysis to compare the score changes before and after medication. Rusults The VAS score of Tongbixiaoti granules group was significantly improved after 2 weeks and 4 weeks of treatment(P<0.05). The clarithromycin tablet group had no significant improvement after 2 weeks and 4 weeks of treatment(P>0.05). Lund Kennedy score showed that there was no significant difference between in the Tongbixiaoti granules group at 2 weeks of treatment, but it was significantly improved after 4 weeks of treatment(P<0.05). Clarithromycin tablets group was not significantly changed(P>0.05). The saccharin test showed that there was no significant improvement in the saccharin clearance time between two groups after 2 weeks of treatment (P>0.05), but the saccharin clearance time of Tongbixiaoti granules group after 4 weeks of treatment was lower than that of clarithromycin tablet group(P<0.05). Concllusion Tongbixiaonti granules can significantly improve the shape and transmission function of the nasal mucosa on CRSsNP, and can promote the recovery of nasal mucociliary function. It is better than clarithromycin tablet group, and has no obvious toxic and side effects, which is worthy of popularization and application.