Objective To investgate the effect of Cheng?蒺s Bixiefenqing Decoction on renal tube function in UAN. Methods Sixty UAN patients with dampness and turbidite stasis type were selected and randomly divided into two groups, the control group and the experimental group, each group has 30 cases. The control group was given routine treatment of febuxostat, and the experimental group was given Cheng?蒺s Bixiefenqing Decoction on the basis of control group. After four weeks of treatment, the serum UA, SCr, BUN, Cys-C levels and urine NGAL, α1-MG, NAG levels were detected. Results The total effective rate of experimental group was significantly higher than that of control group(P<0.05). The levels of serum UA, SCr, BUN and Cys-C levels of the two groups were significantly lower than before the treatment(P<0.05). And the BUN and Cys-C levels of experimental group were significantly lower than those of control group after treatment(P<0.05). The levels of urine NGAL, α1-MG and NAG of the two groups were significantly lower than those before treatment (P<0.05). There were no obvious adverse reactions in the two groups during the treatment. Conclusion Cheng?蒺s Bixiefenqing Decoction can effectively improve kidney function and renal tubule function in UAN patients with dampness and turbidite stasis type, which has definite clinical effect and good safety.