Objective To optimize the matrix prescription and technology of Dragon?蒺s blood cataplasms. Methods On the basis of single factor, with the initial adhesion, viscosity holding force and comprehensive sensory as grading standards, and with viscomate NP-700, dihydroxy aluminum, glycerin, carboxymethylcellulose sodium as influencing factors, and optimize with orthogonal test method. Results Best prescription composition of Dragon?蒺s blood cataplasms was as follows: 5 g of viscomate NP-700, 0.6 g of dihydroxy aluminum, 40 mL of glycerin, 1.0 g of CMC-Na. The cataplasms was with good formability, moderate viscosity, good skin follow ability, and no residue on the matrix. Conclusion The optimized prescription ratio and technology of Dragon?蒺s blood cataplasms is stable and feasible, and can be used for preparation.