Ischemic stroke is a disease with high morbidity and disability, but its mechanism is still unclear and the treatment options are limited. Ferroptosis is a new type of cell death dependent on iron. Recent studies have shown that ferroptosis mediates the death of nerve cells in the injury process of ischemic stroke, which can induce and aggravate the injury after cerebral ischemia, and inhibition of ferroptosis can significantly improve and alleviate the neurological injury induced by cerebral ischemia. In order to provide a new direction for clinical research and treatment of ischemic stroke, this article reviews the main mechanism of ferroptosis, the effect of ferroptosis on ischemic stroke, and the research on ameliorating injury after ischemic stroke by regulating ferroptosis.