Systemic sclerosis is a refractory connective tissue disease, which can be classified into categories such as "skin arthralgia" and "lung arthralgia" in traditional Chinese medicine. Based on the related discussion of Taiyin, combined with the modern medical research of systemic sclerosis and the clinical manifestations of patients, this paper systematically analyzes the correlation between Taiyin and systemic sclerosis, and holds that the basic pathogenesis of the occurrence and development of the disease is that the deficiency of viscera affiliated to Taiyin causes vital Qi deficiency and pathogenic Qi violating, which then affects the metabolism of body fluid, resulting in phlegm turbidity and blood stasis. The therapeutic prescriptions starting from the Taiyin, which can strengthen the spleen and lungs, harmonize Ying and Wei, supplement Qi and nourish blood, have a significant efficacy on systemic sclerosis. This paper expounds the theoretical basis and importance of treating systemic sclerosis from Taiyin so as to provide methods and reference for clinical practice.