Objective To evaluate the effect of Jinshuifuzheng plaster on FeNO, lung function (FEV1, FEV1%, FVC, PEF), immunoglobulin E（lgE） level, eosinophil count and ACT score in patients with chronic duration of bronchial asthma. Methods Seventy two asthma patients who met the inclusion criteria were included in control group and treatment group. The control group was applied with corn flour paste pills(analog), the treatment group was applied with jinshuifuzheng plaster for acupoint application intervention. The treatment, from the beginning of summer to winter, runs within 3 days before and after the early, middle and the end of the hot season in summer, and within 3 days before and after the winter solstice, the second and the third nine-day period after the winter solstice, a total of 6 times. Follow-up was conducted one month after the end of the course of treatment. FeNO, lung function(FEV1, FEV1%, FVC, PEF), immunoglobulin IgE level, eosinophil count and ACT score were counted and analyzed before and after the test. Results (1) Ten patients fell off due to follow-up and 62 were enrolled. (2) The FeNO value of the treatment group was decreased, and there were statistical differences(P＜0.05), while control group showed no significant change (P＞0.05). (3) All indexes of lung function (FEV1, FEV1%, FVC, PEF) improved in the treatment group (P＜0.05). In the control group, FEV1%, FVC, and PEF did not change significantly (P＞0.05), but FEV1 decreased instead (P＜0.05). (4) There were statistical differences in EOS in the treatment group (P＜0.05), no difference in the control group (P＞0.05), IgE in the treatment group (P＜0.05), and no difference in the control group (P＞0.05). (5) The ACT score was significantly improved in the treatment group (P＜0.001), while there was no significant change in the control group(P＞0.05). Conclusion On the basis of conventional treatment of western medicine, acupoint application, with treatment of winter diseases in summer and winter by jinshuifuzheng plaster, is effective in improving asthma symptoms, lung function indicators(FEV1, PEF, FEV1%, FVC) and reducing airway inflammatory reaction in patients with chronic asthma. The clinical efficacy is better than that of conventional treatment of western medicine, and the safety is better.