Objective By summing up Professor Wu Shengyuan?蒺s clinical experience and drug use characteristics in the treatment of osteoarthritis, we analyzed and explored the drug use law of osteoarthritis, providing reference for clinical treatment of osteoarthritis and the development and research of new drugs. Methods Collecting the prescriptions of osteoarthritis patients in the outpatient clinic of professor Wu Shengyuan, then double proofreading was entered into the "Auxiliary platform of inheritance of traditional Chinese medicine(V2.5)", and the frequency of four qi, five flavors and economic use of drugs were used to analyze the combination of drugs by using data analysis and mining methods such as association rule analysis, cluster analysis, unsupervised entropy clustering, complex system entropy clustering, and so on. Results 395 prescriptions were selected and 46 high-frequency drugs with a frequency of more than 10 were selected. Warm and sweet drugs were the most commonly used, and the drugs belonging to the four meridians of spleen, lung, liver and kidney were the most used. Conclusion Professor Wu Shengyuan emphasizes "regulating and tonifying Zhongjiao" and "using sweet and warm drugs to tonify deficiency" in the treatment of osteoarthritis. On this basis, he dialectically chooses the disease as the core and the symptoms as the auxiliary treatment of osteoarthritis, forming a unique experience in diagnosis and treatment.