As a typical representative of non-drug therapy of traditional Chinese medicine, Tuina is widely used in clinics, in which the pivot mechanism is closely related to the structure and functional activities of specific brain regions. With the development of magnetic resonance imaging (MRI) technology, multimodal MRI plays an important role in exploring the central mechanism of Tuina. Taking the advantages of multimodal MRI in non-invasive and high spatial resolution, we can understand the central effect of Tuina and provide an objective and reliable neuroimaging basis for the study of its central mechanism. Therefore, the author reviews the progress of multimodal MRI in the research of the central mechanism of Tuina, to provide some ideas and methods for the research in this field.