"Chong channel being sea of blood" provides important evidences to adjust Qixue and regulate Chongren under the guidance of TCM theory. The review discusses the correlations between physiological functions of "governing permeation", "governing menstruation" and the theory of "chong channel being sea of blood", thus reveals its underlying theoretical basis. Besides, the application based on the theory in gynecological diseases such as acupuncture, Chinese medicine and massage will be discussed as well. In the concept of "blood as the foundation" and "blood as the application" of female physiology, it is with directive significance for the development of theoretical basis in TCM, as well as the treatments in gynecological diseases to explore the theory based on "chong channel being sea of blood".