Objective To study the therapeutic effect of Jiaweishengxian Decoction combined with external diaphragm pacemaker(EDP) on acute exacerbation of chronic obstructive pulmonary disease(AECOPD) with deficiency of Zongqi and phlegm blood stasis. Methods 108 patients were collected and randomly divided into three groups, the test group (routine western medicine treatment combined with EDP, oral administration of Jiaweishengxian Decoction), the control group 1(routine western medicine treatment group) and the control group 2(routine western medicine treatment combined with EDP). The changes of pulmonary function(FVC, FEV1%, FEV1/FVC%), T-lymphocyte subsets(CD3+, CD4+, CD4+/CD8+, CD8+), 6-minute walking test(6-MWT ) and dyspnea score index "Brog score", blood gas analysis (PaO₂, PaCO₂), CAT score, and syndrome score were compared before and after treatment. Results In terms of symptom improvement, the CAT score, total score of TCM syndromes, 6-MWT and Borg score in the test group were better than those in control group 1 and control group 2 after treatment, with significant difference(P<0.01). In terms of immune function improvement, the up regulation of CD3+ and CD4+ in test group was more obvious than that in control group 1 and control group 2, with a statistically significant difference(P<0.05). In terms of improvement of pulmonary function, FEV1% and FVC in the three groups were significantly improved before and after treatment, with a statistically significant difference(P<0.01). There was no significant difference between the three groups before and after treatment, with no statistically significant difference(P>0.05). In terms of the improvement of blood gas analysis, there was no significant difference in PaO₂ between the three groups before and after treatment(P>0.05), PaCO₂ was significantly lower than that before treatment, the difference was statistically significant (P<0.01), PaO₂ and PaCO₂ were significantly changed in the three groups before and after treatment, the difference was statistically significant (P<0.05). Conclusion Jiaweishengxian Decoction combined with EDP can increase the CD3+ and CD4+ of AECOPD patients with Zongqi deficiency and phlegm blood stasis, thus improving their immunity. The PaO₂, PaCO₂ value is improved and the patient?蒺s ventilation is increased. The CAT score and the total score of TCM syndromes were reduced, the 6-minute walking test distance was increased, the clinical symptoms were improved, and the quality of life of patients was improved.