Objective Through the visualization of knowledge graph, the research status, research hotspots and research results of anti-tumor angiogenesis of traditional Chinese medicine (TCM) in the past 20 years was explored, in order to provide reference for further research in this field. Methods With "traditional Chinese medicine", "tumor angiogenesis", etc. as the theme words. The period is from January 1, 2002 to December 31, 2021. The relevant literature included in the Chinese National Knowledge Infrastructure(CNKI) was searched. Used the CiteSpace.6.1.R1 software to conduct the metrological analysis of the literature, and drew, analyzed the relevant knowledge map. Results In total, 608 analytical articles were included. From 2002 to 2021, the number of domestic literatures on anti-tumor angiogenesis of TCM showed an overall upward trend, the number of articles reached its peak in 2010, with 47 articles. The total number of articles published by the core authors is 437, accounting for 71.87% of the total (>50%). A total of three closely cooperative author organizations have been formed. The high-frequency