Objective To observe the effects on peripheral interferon γ(interferon γ, IFN-γ), and interleukin 8(interleukin8, IL-8), to explore the immune regulation mechanism of this effect on cough variant asthma，and to provide an experimental basis for the development of traditional Chinese medicine. Methods CVA model mice were replicated and randomly divided into 5 groups. Each group was treated for 3 weeks to obtain blood from serum IFN-γ and IL-8. Results The treatment of CVA may be related to changing IL-8 and IFN-γ in the serum of mice, which can significantly increase the serum levels of IFN-γ and reduce IL-8 in CVA model mice. Conclusion By increasing the level of IFN-γ, it can significantly reduce the inflammatory response of IL-8 in CVA model mice, and has anti-airway inflammation and immune system regulation, which may be one of the mechanisms of the compound treatment of CVA with traditional Chinese medicine.