Renal osteopathy is a common complication of end-stage renal disease, which seriously affects the survival and prognosis of patients. The common types of renal osteopathy, its evolution, clinical treatment and basic experimental research progress were analyzed retrospectively. The main syndrome types of renal osteopathy are liver and kidney Yin deficiency syndrome, spleen and kidney Yang deficiency syndrome, blood stasis syndrome, turbidity toxin syndrome. The clinical treatment includes compound decoction, Chinese patent medicine, combination of needle and medicine, foot bath, enema and other treatment methods. Basic experiments were mainly conducted on Wnt/β-catenin pathway, BMP-7 pathway, FGF23/ Klotho pathway and osteoprotegerin (OPG).