Objective To explore the effect of acupuncture and massage treatment combined with Xianlinggubao capsule in patients of non traumatic necrosis of the femoral head with clinical early or medium stage. Methods Patients diagnosed with early and middle stage femoral head necrosis were randomly divided into treatment group and control group. Patients took Xianlinggubao capsule orally in control group for 6 months. Patients was treated with Xianlinggubao capsule, acupuncture and massage in treatment group for 6 months. At the same time, patients had functional exercise of crutches and hips in each groups. Harris score, VAS score and overall image stability rate were used to assess the clinical efficacy. Results The total effective rate in treatment group (91.67%) was significantly higher compared with control group (72.91%) (P<0.05). The Harris score(94.90±4.93) and overall image stability rate(95.83%) in treatment group was significantly higher than control group (91.66±8.22) (P<0.05) and (64.58%) (P<0.05). The VAS score treatment group (1.84±0.71) was significantly lower compared with control (2.68±0.74) (P<0.05). Conclusion The clinical effect of Xianlinggubao capsule treatment combined with acupuncture and massage in early and medium stage non traumatic femoral head necrosis (phlegm and blood stasis blocking collaterals syndrome in Chinese medicine) is better than that of Xianlinggubao capsule alone. It can significantly relieve patients‘ pain. It is of great value for widely clinical application and deeply exploration.