Objective To analyze the studies about systematic review and Meta-analyses of heart failure in the treatment with Yiqi Fumai injection. Methods Two researchers screened literature and extracted data in four Chinese databases and four English databases from inception of them to June 2022. Two researchers independently used PRISMA statement to evaluate the study quality, and used AMSTAR 2 to assess the methodology quality, GRADE tool to analyze the evidence quality of the findings. Results A total of 7 Meta-analyses were included, the PRISM score was between 21 and 25.5, 6 of the findings were almost completed, 1 of them had a certain of defect. The AMSTAR 2 evaluation results showed a generally low level, 4 of them were low, 3 of them were very low. GRADE tool evaluated 32 outcome indicators, and 3 were middle, 13 were low, 16 were very low. Conclusion HF treated by Yiqi Fumai injection has a certain efficacy and safety. However, due to the low methodology and evidence quality inclusion literatures, this conclusion only provides a certain reference. In order to provide a better evidence-based evidence for HF in the treatment with Yiqi Fumai injection, further studies should be indeed.