Central fatigue is one of the subtypes of fatigue, which is due to the dysfunction of the central nervous system, resulting in a series of fatigue-like reactions in the body, nerves, and psychology. In recent years, the incidence of central fatigue has increased, which has become the main problem that plagues people's health. Combining with the concepts and characteristics of modern medicine, this paper expounds the theoretical connotation and syndrome differentiation of central fatigue in TCM, and analyzes and discusses from the etiology, pathogenesis, symptoms and other aspects.The location of disease is spleen, and the nature of that is dampness. Treating central fatigue from spleen deficiency and excess dampness is in line with the fatigue state of modern people.