This paper mainly expounds the physiological function and pathological changes of the liver, the etiology, treatment principle and prescription of liver diseases in Dai medicine. Liver diseases in Dai medicine is due to a variety of endogenous and exogenous factors that cause dysfunction of the Sitawuyun in the body, cause water and blood movement not smooth, and eventually result in physiological dysfunction of the liver. Tiaoping Sitawuyun, preventing disease before it occurred, detoxifying before treating, and dredging the Sanpan are the treatment principle. The characteristics in the prevention and treatment of liver disease of Dai medicine are: on the treatment methods, the internal treatment of the main, and external treatment of the auxiliary; on the drugs, detoxification drugs are preferential, different towers use different drugs, and more the tower drugs are selected.