Objective To explore the rule of clinical acupoint selection for hiccup after stroke based on neuroelectrophysiology and regulation. Methods Literatures related to acupuncture in the treatment of hiccup combined with stroke in four Chinese databases (CNKI, Wanfang, VIP, CBM) from January 1, 2000 to December 31, 2021 were searched and sorted out, and the acupuncture prescription database for hiccup after stroke was established. The SPSS 21.0 and Clementine12.0 were used for descriptive analysis and association rule analysis and to analyze the acupoint selection rule of acupuncture treatment for hiccup after apoplexy. Results Filtered with a total of 111 articles were included in the standard, the statistics of 200 acupuncture prescription of acupuncture and moxibustion treatment of post-stroke hiccups, involved 88 acupoints, the total frequency of 1 143 times, the most frequently used acupoints were: Neiguan, Zusanli, Zhongwan. The location of the selected acupoints is mainly the chest and abdomen acupoints, a total of 14 prudes are involved, and acupoints of Conception Vessel are the most frequently used. By using technology of association rule, the highest correlation between acupoints is Neiguan-Zhongwan-Zusanli. Conclusion Acupuncture and moxibustion treatment after stroke hiccup formula has regularity, moreover, it is different from simple hiccup in the selection of points, which is reflected in the compatibility of selected points and acupoints. It pays more attention to brain synergy with visceral and nerve function regulation. This study provides theoretical support and reference for the selection of acupuncture points for the treatment of hiccup after stroke.