Wa medicine is an important part of ethnomedicine in China. The study found that due to its unique climate features and dietary habits, the incidence of spleen and stomach diseases is more high in the settlements of the Wa people, such as stomach pain, dysentery, and diarrhea. Wa medicine has unique experience in the use of spleen and stomach system-related diseases. However, due to the backwardness of inheritance methods, some drug experience has been faced with the risk of being lost. In order to excavate and inherit its experience, the author integrated local literature, visited two Wa autonomous counties in China(Ximeng and Lancang) , and communicated local Wa doctors, and finally summed up 218 prescriptions of spleen and stomach diseases. Then, Wa medicine of application and modern pharmacology in diseases of the spleen and stomach system were discussed in this paper with analyzing its characteristic medication rules, summarizing the efficacy of high-frequency drugs used in Yunnan.