Objective To investigate the status quo of clinical trials on TCM intervention with cancer-related fatigue(CRF) registered in Chinese clinical trial registry(ChiCTR). Methods The CRF clinical research registration trials related to TCM included in ChiCTR database were searched from the establishment of the database to June 2, 2022, and the search results were screened and the required data information was extracted. The selected data were statistically analyzed by using the form function of WPS Office software, and the characteristics of clinical trials were summarized. Results A total of 36 TCM related clinical trials of CRF were included, covering 6 provinces and 3 municipalities in China, including 34 intervention studies and 2 observational studies, with a sample size of 5327 patients. Intervention measures included Chinese medicine oral therapy, Chinese medicine injection, external treatment and traditional Chinese medicine Gongfa. Conclusion The number of CRF TCM clinical trials registered is generally on the rise, and the trials are mostly randomized controlled trials(RCTs), mainly intervention studies. Their spatial distribution is not balanced, and the rigor of registration information and the standardization of outcome indicators need to be further improved.