Objective To explore the mechanism of opening Xuanfu method in the treatment of mild cognitive impairment. Methods By sorting out the relationship between the Xuanfu and mild cognitive impairment, we explored the mechanism of opening Xuanfu method, such as nourishing the Xuanfu puzzle, opening wisdom and transporting Xuanfu to produce wisdom, in the treatment of mild cognitive impairment. Results The location of mild cognitive impairment is in the brain, the depression of the Xuanfu is an important cause, and Xuanfu the brain may be related to the blood-brain barrier. Opening Xuanfu can improve cognitive function in patients with mild cognitive impairment. Conclusion The method of opening Xuanfu may work by adjusting the permeability of the blood-brain barrier and improving the internal and external environment of the brain. By nourishing the spleen and kidney to nourish the Xuanfu and enlighten the mind, removing phlegm and eliminating stasis to open the Xuanfu to transport the xuan and generate wisdom, the effect of opening Xuanfu and benefiting brain can be achieved together to improve the cognitive function of patients with mild cognitive impairment.