Objective To observe the clinical effect of aromatherapy combined with Yiguanjian on sleep and anxiety of syndromes of kidney deficiency and liver depression before and after Jingduan. Methods In this project, 60 cases of patients with kidney deficiency and liver depression who met the inclusion criteria before and after Jingduan were randomly divided into a control group and a treatment group, 30 cases in each group. The control group was given oral treatment of Yiguanjian, the treatment group was given topical application of true lavender essential oil plus oral treatment of Yiguanjian. The treatment period of the two groups was one month. The patients with syndromes of kidney deficiency and liver stagnation before and after Jingduan were observed with the score scale of syndromes of kidney deficiency and liver depression, Pittsburgh sleep quality index(PSQI), modified Kupperman scale(KMI), and Hamilton anxiety scale (HAMA). Results The curative effect of TCM symptoms, PSQI single symptom and total score, Kupperman single symptom (except nervousness and anxiety symptoms in the control group), and Hamilton anxiety scale scores of the two groups were lower than those before treatment(P<0.05). Moreover, the total score of PSQI, the score of insomnia, nervousness, anxiety, depression symptoms and Hamilton anxiety scale score of the treatment group were better than those of the control group (P<0.05); the sleep effect of the treatment group was better than that of the control group, with statistical significance clinical significance(P<0.05); the total clinical effective rate of the treatment group was 83.33%, and that of the control group was 73.33%, and the difference between the two groups was statistically significant (P<0.05). Conclusion Adding aromatherapy on the basis of Yiguanjian can improve the curative effect of TCM syndromes, improve sleep quality, menopausal syndrome and anxiety state, and it is better than oral administration of Yiguanjian alone. It can be popularized and applied in clinic.