Objective To observe the efficacy and side Yishen Shengbai Plaster combined with acupoint injection on myelosuppression caused by chemoradiotherapy in malignant tumors. Methods Chemotherapy were randomly divided into three groups, 35 patients were treated with combined acupoint injection dexamethasone, 35 patients with only acupoint injection dexamethasone treatment as a control group 1, 31 patients with recombinant human granulocyte colony-stimulating factor subcutaneous injection treatment as a control group 2. Bone marrow function recovery and drug adverse effects were observed. Results There was no statistical difference in recovery time and total response rate(P>0.05). The three groups underwent chemoradiotherapy and bone marrow function was significant(P<0.05) in the treatment group of dexamethasone injection. None of the three groups of patients had special adverse effects. Conclusion Bone marrow suppression combined with acupoint injection is safe and effective, and has no obvious adverse effects against bone marrow function, which is worthy of clinical application.